Blood-pressure variability and hypertensive control in patients with renal failure - the potential for smoother and superior control of mean blood-pressure and episodic hypertension through higher-dose dialysis.

In dialysis patients, does higher-dose renal replacement provide better control of blood pressure when compared to standard dose therapy?

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000929606

Enrollment

Registered

2014-08-29

Start date

2014-10-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To date no prospective study has been undertaken to investigate the effect of haemodialysis dose delivery on the epidemiology and biological effect of blood pressure variability. This study represents the first comparative investigation between peritoneal dialysis, extended-hours haemodialysis and conventional thrice-weekly satellite therapy, with the expectation of objectively demonstrating smoother and better control of blood pressure using home-based therapies. This study hypothesises that patients undergoing therapies with high-dose dialysis achieve better control of blood pressure with less time spent in hypertensive ranges and less blood pressure variability than patients undergoing conventional thrice-weekly satellite haemodialysis

Interventions

Prevalent patients undergoing extended hours / home based therapy : Haemodialysis (>6hour treatment at a frequency of alternate nightly or greater = >20hrs treatment/week) OR peritoneal dialysis (conventional ambulatory peritoneal dialysis or overnight automated peritoneal dialysis). Patients must be established on therapy for at least 3 months. Patients will be observed over one dialysis treatment and subsequent interdialytic period.

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

End-stage renal disease requiring dialysis

Exclusion criteria

Renal replacement for <3 months

Outcome results