Cough Reflex after Intubation (CRAIn)

Recovery of Cough Following Extubation after Coronary Artery Bypass Grafting: A Prospective Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000917639

Acronym

CRAIn

Enrollment

100

Registered

2014-08-27

Start date

2013-01-22

Completion date

2013-09-08

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Participants undergoing CABG had a baseline cough reflex test (CRT) before surgery/intubation. The CRT was repeated within two hours of extubation. Participants with no change for their baseline had no further testing as cough was considered unchanged. Participants with absent cough were retested every morning and evening until baseline cough returned or the participant withdrew, was discharged or died. The cough reflex is an important airway clearance mechanism that protects the airway from aspiration. The researchers wanted to determine how long patients' cough is absent after intubation and if any variables are predictive of recovery.

Interventions

Participants underwent cough reflex testing (CRT) before intubation and after extubation for coronary artery bypass grafting. This study was observational. CRT is performed by asking the participant to inhale nebulised citric acid. The citric acid is presented via face mask. The participant is instructed to "try not to cough". If the participant produced a cough on 2 out of 3 trials their cough was considered present. Three concentrations of citric acid, 0.4, 0.8 and 1.2 mol/L, were interspersed with normal saline trials to establish each participant's baseline. Baseline CRT was performed before surgery and follow-up CRT was performed within two hours of extubation and then every morning and evening until the participant had a present cough at baseline level, withdrew or was discharged from hospital.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Adults undergoing coronary artery bypass grafting

Exclusion criteria

Patients having valve replacement, history of dysphagia, head and neck cancer or neurological condition, abnormal cough reflex at baseline

Outcome results