The CUBA Study - Cane Use and Bone marrow lesions in knee osteoArthritis

The CUBA Study: The impact of cane use on bone marrow lesion size in people with medial compartment knee osteoarthritis: a randomized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000909628

Acronym

CUBA

Enrollment

120

Registered

2014-08-26

Start date

2015-04-24

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Osteoarthritis (OA) is a major and costly cause of chronic musculoskeletal pain and disability in Australia. Patient self-management strategies are urgently needed. In knee OA, increased joint loading (forces acting across the joint) leads to worse knee pain and progressive structural joint deterioration. This project will investigate the impact of daily cane use, an easy and inexpensive self-help tool known to unload the knee, applied for 3 months on bone marrow lesion size on MRI in people with medial knee OA.

Interventions

Intervention: contra-lateral use of a cane to unload the affected medial knee compartment. Participants will be instructed to use the cane daily whenever walking for 3 months. Cane use and possible adverse events will be monitored in self-reported log books. Participants will receive reminders during the intervention to maximize adherence to cane use.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Investigator)

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

Aged>50; Knee pain on most days of the last month; Kellgren-Lawrence grade 2 or above and definite medial tibiofemoral compartment OA on x-ray (grade 1 or higher medial joint space narrowing and joint space narrowing grade medial>lateral); Presence of at least one bone marrow lesion in the medial knee compartment on MRI;

Exclusion criteria

History of knee surgery ie joint replacement and tibial osteotomy in either knee and/or planning to undergo knee or hip surgery in the next 3 months; Other muscular, joint, neurological conditions other than knee OA affecting lower limb function or interfering with daily cane use; Current and previous (ie previous 3 months) use of canes; Current and previous (ie previous 3 months) irregular use of shoe inserts, knee or ankle braces or customized shoes prescribed by a health professional; Current and previous treatments (ie previous 6 months) of knee arthroscopy and intra-articular injections in the knee; Contra-indications for MRI; Use of potential disease-modifying drugs;

Outcome results