None listed
Conditions
Brief summary
Study design: 12-month randomised, double-blind, placebo-controlled intervention trial with 4 measurement points. Participants: 72 men & women, aged 60-90 years with Mild Cognitive Impairment. Intervention: Half the participants will receive fish-oil capsules and the other half will receive placebo capsules for 12 months. Outcome measures: cognitive performance, well-being, blood pressure and weight. Demographic and nutritional data will be collected as covariates.
Interventions
12 month intervention of 1500 mg of docosahexaenoic acid (DHA) and 300 mg of eicosapentaenoic acid (EPA) per day. Participants will take 3 x 500mg of DHA+100mg of EPA capsules in the morning with breakfast every day for 12 months. Participants will be given 4 bottles of capsules (each containing 200 capsules) at the end of the baseline testing session, another bottle at the end of the 2nd session and the final bottle at the end of the 3rd testing session. Participants will be required to return
12 month intervention of 1500 mg of docosahexaenoic acid (DHA) and 300 mg of eicosapentaenoic acid (EPA) per day. Participants will take 3 x 500mg of DHA+100mg of EPA capsules in the morning with breakfast every day for 12 months. Participants will be given 4 bottles of capsules (each containing 200 capsules) at the end of the baseline testing session, another bottle at the end of the 2nd session and the final bottle at the end of the 3rd testing session. Participants will be required to return the capsule bottles with all unused capsules to the following testing sessions.
Sponsors
Alexia Mengelberg
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria for participants will be a diagnosis of cognitive impairment based on neuropsychological assessment and self-reporting. Agree to not start taking own fish oil supplement during the 12-month trial. .
Exclusion criteria
Major medical conditions including head injury or recent major surgery, problem swallowing capsules, consumption of 3 more more servings of oily fish per week, consumption of fish oil supplements in the last 12 months and an allergy to fish or seafood.
Outcome results
None listed