Fluid treatment for severe infections in children

Fluid resuscitation for severe paediatric sepsis: what are the effects on stroke volume, IVC collapsability, and lung ultrasound score?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000824662

Enrollment

Registered

2014-08-04

Start date

2014-02-06

Completion date

2017-02-10

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

: This PhD study is an observational cohort study of fluid resuscitation in children with severe sepsis. The primary aim is to determine the effect (both in size and duration) of fluid bolus therapy on stroke volume in children with severe sepsis. Secondary aims include: the ability if IVC ultrasound to predict fluid responsiveness; the ability of lung ultrasound to detect early harms from fluid bolus administration; and the correlation between fluid bolus administration and changes in vital signs.

Interventions

Transthoracic echocardiogram to measure stroke volume pre and post fluid bolus administration. Additional measurements: IVC collapsability, extra-vascular lung water estimation on lung ultrasound, and clinical signs (heart rate, blood pressure, respiratory rate, saturations, respiratory effort, conscious state) pre and post fluid bolus administration.

Eligibility

Sex/Gender

All

Age

1 Days to 18 Years

Healthy volunteers

Inclusion criteria

Suspected infection (hyperthermia or hypothermia), cardiovascular compromise (tachycardia and abnormal capillary refill time or hypotension), and a clinical decision to administer a standardised fluid bolus (20ml/kg 0.9% saline).

Exclusion criteria

Underlying structural cardiac disease, English as a second language in whom true informed consent cannot be obtained, those whose goals of therapy are non-curative.

Outcome results