None listed
Conditions
Brief summary
This study aims to examine the effect Citalopram (a common SSRI medication) has on the body's response to light exposure at night. It is hypothesised that as compared to placebo trials, administration of Citalopram will will result in an altered response to night time light exposure.
Interventions
Participants will be asked to attend 4 test sessions of ~5 hours each, with ~one week between each session. Each session commences ~4 hours before the participants' habitual bedtime, concluding 1 hour after.
The first two sessions will be dim-light exposures (<1 lux), with citalopram 30mg being administered on the first evening, and placebo on the second. The first evening serves to confirm that citalopram 30mg does not influence absolute levels of melatonin, which would impede our ability to
Participants will be asked to attend 4 test sessions of ~5 hours each, with ~one week between each session. Each session commences ~4 hours before the participants' habitual bedtime, concluding 1 hour after. The first two sessions will be dim-light exposures (<1 lux), with citalopram 30mg being administered on the first evening, and placebo on the second. The first evening serves to confirm that citalopram 30mg does not influence absolute levels of melatonin, which would impede our ability to measure the suppression of melatonin during the following light exposures. The second night serves as a dark-control for subsequent light exposures. The final two nights are light exposures (~100 lux) with participants being randomised to receive either citalopram 30mg, or placebo, first. Each participant will be exposed to both conditions. A single capsule of citalopram 30mg (or matched placebo) will be administered in the laboratory ~4 hours prior to each participants' bedtime according to their sleep-wake schedule. This takes place during all in lab sessions.
Sponsors
Monash University
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy Caucasian males and females
Exclusion criteria
- Any history of psychiatric illness or use of psychiatric medication - Current sleep disorders or erratic/unusual sleep patterns - Recent or excessive illicit drug use - Current use of any prescription medication - Colourblindness - Recent surgery involving a full anaesthetic - Any night shift within the past 3 months - Any travel outside of the current time zone within the last 3 months - BMI less than 18 or greater than 30 - Epworth Sleepiness Scale score greater than 10 - Beck Depression Inventory score greater than 13 - Use of hormonal contraception - Abnormal menstrual cycle (<21 days or >35 days in length or irregular/unpredictable)
Outcome results
None listed