None listed
Conditions
Brief summary
Labour analgesia in the form of epidural would be ideal for all parturients but this being expensive to provide is limited in supply to only about 1% of the Malaysian population. Dose finding studies have shown that 0.8% sevoflurane administered to a parturient can provide substantial analgesia. A commercially available 0.8% inhaler has just emerged in the market. We would like to compare this method with the traditional option of using Entonox. In this study we propose to compare the pain experience of parturients exposed to either 0.8% sevoflurane or entonox. We expect the 0.8% inhaler to provide better analgesia for the mother. We do not expect any untoward complications to arise from its use. The costing results will be unknown until after the study.
Interventions
Comparison of sevoflurane 0.8% and nitrous oxide 50% in oxygen for labour analgesia. Sevoflurane 0.8% will be administered as an inhalational agent using the Diamedica draw over vaporiser with a fixed concentration of 0.8% in air. Entonox will be administered via the Entonox inhaler attached to the hospital wall supply.
Both agents will be given as patient controlled inhalers throughout the duration of labour
Sponsors
University of Malaya
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
Yes
Inclusion criteria
Healthy parturients in active labour with no medical or surgical comorbidities
Exclusion criteria
Any coexisting medical or surgical comorbities to mother and fetus
Outcome results
None listed