Cell and Molecular Biology of Vascular Anomalies

The effect of biologically significant pathways (such as the Renin-angiotensin system) on biological processes including haematopoiesis, in the regulation of vascular anomalies in a population of both adult and paediatric patients with vascular anomalies.

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000792628

Enrollment

500

Registered

2014-07-25

Start date

2014-05-01

Completion date

2023-10-07

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We will use frozen and formalin fixed tissues from our tissue bank, freshly excised surgical specimens and up to 10mls of patient serum and urine from both patients treated surgically and medically, to investigate the cause of vascular anomalies including vascular tumours (such as infantile haemangioma) and vascular malformations including arterial, venous, lymphatic malformation and arteriovenous malformations. Recent research by our group has found the involvement of stem cells and the Renin Angiotensin system (RAS) in the regulation of infantile haemangioma proliferation and involution. We seek to continue to explore the cellular and biological pathways that govern the growth of these vascular tumours and apply our knowledge in the investigation of other vascular anomalies, including expression of haematopoietic, vascular endothelial growth factor and the RAS pathways.

Interventions

The programmed biologic behaviour (ie. rapid growth and slow but inevitable regression involution) of infantile haemangiomas is precisely controlled by the interaction between cells and their niche. We intend to use freshly excised and frozen, and parrafin fixed vascular anomaly tissues to further investigate the cellular mechanisms leading to these lesions. We are also looking for further evidence to substantiate our recent published findings on biologically significant pathways, such as the effect of hormonal systems including the renin-angiotensin system on biological processes including haematopoiesis, in the regulation of these vascular anomalies. The patients in this study after signing a consent form, have their vascular anomaly tissue excised under general anesthetic. It is then entered into our onsite tissue bank - in either snap frozen or paraffin blocked form. As hypothesis surrounding the mechanisms and biology of vascular anomalies are postulated, tissue is taken from the tissue bank for analysis. The is a broad ranging study and is ongoing, and has an ethics approved end date of 01.01.2023

Eligibility

Sex/Gender

All

Age

0 to 100 Years

Healthy volunteers

Inclusion criteria

Any patient undergoing surgical excision of a vascular anomaly who and/or their caregiver/parents give consent for the specimen to be stored in the tissue bank and used for research. Lesions including vascular tumours (such as haemangioma) and vascular malformations including capillary, venous and lymphatic.

Exclusion criteria

Any patient/caregiver who does not wish to give consent for their specimen to be used for research, and any specimen that is deemed inappropriate (too small) for research by the pathologist receiving that specimen. If a patient consents to donate their tissue to the tissue bank, but declines to donate the requested serum and/or urine samples, their tissue will still be added to the tissue bank as per their consent.

Outcome results