Effects of Sevoflurane and Desflurane on otoacoustic emissions (OAE) in healthy adult patients with normal hearing tests undergoing septoplasty and turbinoplasty surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000758606

Enrollment

Registered

2014-07-17

Start date

2012-06-20

Completion date

2013-02-28

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To determine the influence of the new short acting inhalation agents;desflurane and sevoflurane which are widely used in general anaesthesia on otoacoustic emissions (OAEs) in humans. Otoacoustic emissions measured under desflurane and sevoflurane anaesthesia. Both agents effect the systemic blood pressures and OAEs. Desflurane and sevoflurane effect OAE measurements by several mechanisms

Interventions

Arm 1: sevoflurane 2% by inhalation from induction until the end of the operation Arm 2: desflurane 5% by inhalation from induction until the end of the operation

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

Healthy patients with normal hearing tests who underwent septoplasty and turbinoplasty surgery

Exclusion criteria

1.abnormal hearing test 2. TEAOE levels less than 3 dB SPL ( decibel -Sound pressure level ) or DPOAE levels less than 6 dBSPL in the preoperative measurements

Outcome results