Oxford Unicompartment Knee replacement versus total knee replacement: a randomised controlled trial

Functional outcomes of arthroplasty for medial compartment osteoarthritis of the knee: a randomised controlled trial of Oxford unicompartmental arthroplasty versus total knee arthroplasty

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000734662

Enrollment

100

Registered

2014-07-11

Start date

2016-02-15

Completion date

2018-12-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Arthritis of the inner part of the knee is common. The most commonly used surgical treatment for this condition is total knee joint replacement. This is effective, however a knee replacement is inferior in function to the non-arthritic knee. An alternative to total knee replacement is replacement of the inner part of the knee only, thus preserving the non-arthritic parts of the knee (termed a unicompartmental replacement). Possible advantages of this include more normal motion and feeling of the knee after surgery. Possible disadvantages include durability inferior to total knee replacement. There have been few good studies comparing the 2 alternatives. This study aims to compare patient satisfaction and durability of unicompartmental knee replacement and total knee replacement.

Interventions

Uncemented Oxford Medial Unicompartmental knee replacement involves replacement of the arthritic medial compartment of the knee with an uncemented metal tray on the medial tibial plateau, an uncemented metal replacement of the medial femoral condylar articular cartilage, and a layer of mobile polyethylene inserted between the 2 components. The duration of the operation will vary, but will be in the vicinity of 60 minutes.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

Anteromedial osteoarthritis of the knee, intact ACL, preservation of full thickness lateral compartment cartilage on valgus stress XR, correctable intra-articular varus, flexion deformity less than 15 degrees.

Exclusion criteria

Inflammatory arthritis, ACL deficiency, MCL deficiency, lateral compartment OA, bone on bone lateral patellofemoral OA + lateral patellar subluxation

Outcome results