None listed
Conditions
Brief summary
to study the effect of prophylactic use of low dose aspirin and heparin on patients with recurrent unexplained pregnancy loss Methods: prospective case control study conducted on 180 pregnant women randomized into 2equal groups. Group 1 received low dose aspirin 75 mg and heparin 5000 IU subcutaneous every 12 hours. Group 2 received no treatment
Interventions
180 pregnant women with history of recurrent unexplained pregnancy loss classified into 2 groups Group 1 included 90 women received low dose aspirin orally 75 mg once daily and heparin 5000 IU subcutaneous every 12 hours started at 8 weeks gestation till the end of 12th week. Group 2 included 90 women received no treatment. Monitoring adherence to treatment was done by counting drug tablets return and counting number of used syringes every 2 weeks
Sponsors
Ahmed Maged
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
19 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. Gestational age 5-7 weeks 2. history of three or more spontanous abortions without an obvious cause
Exclusion criteria
1. Participants with documented cause of recurrent abortion as antiphospholipid syndrome 2. history of thrombo-embolic manifestations 3.medical disorder as diabetes or hypertension 4. chronic disorder like renal cardiac or liver disease 5.those with structural anomalies of the uterus
Outcome results
None listed