None listed
Conditions
Brief summary
The administration of intravenous (IV) crystalloid fluids (also known as fluid therapy) is a ubiquitous intervention in patients undergoing surgery. Worldwide, the most commonly used crystalloid fluids available for patients undergoing major surgery include Saline (0.9%), Hartmann’s and Plasmalyte solutions. All three solutions are available for IV use at Austin Hospital and considered standard of care for all patients undergoing major surgery. Choice of these fluids amongst anaesthetists at Austin Hospital is similar to worldwide practices. In this study we will be collecting information about intravenous fluid intervention (type of fluid and amount) for adult patients undergoing major surgery (duration greater or equal to 2 hours and at least one overnight stay). Data will be collected over a 12-week period. Specifically, the effects of these fluids on kidney function will be investigated. Perioperative care and fluid intervention therefore will remain completely at the discretion of the treating clinicians.
Interventions
The study will investigate the effects of intravenous fluid (type of fluid and amount) for adult patients undergoing major surgery (duration >2 hours and at least one overnight stay) over a 12-week period. The study will determine the association between perioperative intravenous fluids and acute kidney injury (AKI), defined by an increase in creatinine greater than 25% or 0.5 mg/dL (44 micromol/L) from baseline to peak value within the first 72-hours postoperatively.
Sponsors
Austin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult patients greater or equal to 18 years of age 2. Elective or emergency surgery 3. Surgery duration greater or equal to 2 hours 4. Requiring at least one overnight stay
Exclusion criteria
1. Less than18 years of age 2. Liver transplantation
Outcome results
None listed