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Examining effects of whole grain cereals on weight and metabolic markers in humans

Will eating polyphenol-rich whole grain cereal foods, whilst following a weight reduction diet, result in greater weight loss and improved metabolic markers in overweight and obese adults?

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12614000640606
Acronym
GWS
Enrollment
60
Registered
2014-06-18
Start date
2014-07-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project aims to investigate the effects of consuming whole grain foods, whilst following a weight reduction diet for 3 months, on body weight as well as indicators of disease including cholesterol levels, blood levels of insulin and glucose, blood pressure, inflammation markers and antioxidant measures. Therefore, this study is a very important step towards building evidence for specific whole grains as important foods in appetite control that may aid weight loss, as well as reduce the risk of disease.

Interventions

3 month double blinded parallel randomised controlled trial with 2 arms: control (standard grain diet) and intervention (polyphenol-rich grain diet). All subjects are blinded to their control/intervention group status. Both control and intervention arms will attend the clinic at baseline, 1, 2, 3mo for a face-to-face session with an Accredited Practising Dietitian. Duration of sessions are upto 1.5h at baseline and 30-45 minutes for other visits. All subjects receive identical dietary advice, bu

3 month double blinded parallel randomised controlled trial with 2 arms: control (standard grain diet) and intervention (polyphenol-rich grain diet). All subjects are blinded to their control/intervention group status. Both control and intervention arms will attend the clinic at baseline, 1, 2, 3mo for a face-to-face session with an Accredited Practising Dietitian. Duration of sessions are upto 1.5h at baseline and 30-45 minutes for other visits. All subjects receive identical dietary advice, but the intervention group will receive polyphenol-rich cereal products (124.5mg gallic acid equivalents per 60g of cereal per day) and the control group will receive standard cereal products (75.6mg gallic acid equivalents per 60g of cereal). These polyphenols are the natural levels in the processed products. All diets are based on the core food groups outlined in the Australian Guide to Healthy Eating. Prescribed energy intakes will be calculated to equate to individuals’ estimated energy requirements using the Schofield equation and applying a physical activity factor of 1.3. Cereals provided were modelled into the dietary prescription to achieve macronutrient intakes of approximately 50% energy from carbohydrates, 20% from protein and 30% from fat. Adherence to diets will be monitored using repeated 3-day food records at midpoint (6 weeks) and at 3 months, as well as through dietary interviews at 1mo, 2mo and 3 mo.

Sponsors

University of Wollongong
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Men and women from the Illawarra community (adults aged 18-65 years, permanent resident, community dwelling), at higher risk of lifestyle related disease defined by current risk factors such as hypertension, impaired glucose tolerance, hyperlipidaemia and BMI range 25-35kg/m2

Exclusion criteria

Severe medical conditions impairing ability to participate in study; BMI<25 and >35; eating habits incompatible with study goals including food allergies; reported illegal drug use or regular alcohol intake associated with alcoholism (>50g/day); pregnant, breastfeeding and post-menopausal women; difficulties or major impediments to participating in the components of the study including aversion to consuming wholegrain cereal products daily for breakfast and a snack; inadequate conversational English

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026