None listed
Conditions
Brief summary
Sedentary behavior is a risk factor for cardiovascular disease and type 2 diabetes. Observational studies indicate that regularly interrupting sedentary behavior with short bouts of physical activity lowers this risk. The results of two acute intervention trials provided strong experimental evidence that breaking prolonged sitting with regular short bouts of physical activity positively effected postprandial glucose and insulin concentrations. However, the effect of interrupting prolonged sitting with brief bouts of physical activity on postprandial lipid concentrations is still not fully understood. To address this we will conduct a well-designed experimental trial to examine the potential cardio-metabolic benefits of regularly breaking prolonged sitting with short bouts of physical activity. This study will ensure that future physical activity guidelines and public health policies around limiting periods of prolonged sitting are based on sound, experimental evidence.
Interventions
Participants will complete, in random order, three intervention periods and one control period. Each period will be separated by six days and will be conducted on two consecutive days; 7.5 hours from 8:30 am to 4:00 pm on the first day, and 6 hours from 7:30 am to 1:30 pm on the second day.
The three interventions periods are as follows:
1. Physical activity: participants will walk on the treadmill at 60 % of maximal oxygen consumption (VO2max) for 30 min at the end of day one of the trial, at a
Participants will complete, in random order, three intervention periods and one control period. Each period will be separated by six days and will be conducted on two consecutive days; 7.5 hours from 8:30 am to 4:00 pm on the first day, and 6 hours from 7:30 am to 1:30 pm on the second day. The three interventions periods are as follows: 1. Physical activity: participants will walk on the treadmill at 60 % of maximal oxygen consumption (VO2max) for 30 min at the end of day one of the trial, at all other times they will be seated 2. Regular Activity Breaks: participants will walk on the treadmill at the same speed and incline as the physical activity intervention, for 2 min every 30 min throughout both day one and day two the trial 3. Regular activity breaks and physical activity: participants will walk on the treadmill for 2 min every 30 min throughout day one and two. In addition they will also complete 30 min of continuous walking at the end of day one. All walking on the treadmill will be at the same speed and incline as the physical activity intervention The control period is: Prolonged Sitting: participants will remain seated for the duration On day one of each trial participants will be fed standardised meals at 15 and 205 min, and be provided with a standardised meal to consume at home during the evening between day one and two. On day two of each trial participants will be fed a standardised test meal providing 0.7 g fat per kg body mass at 0 min. At 305 min participants will be provided a buffet lunch.
Sponsors
Meredith Peddie
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy men and women who do not regularly undertake more than 3 hours of physical activity a week, and have a predominantly sedentary occupation
Exclusion criteria
Pregnancy; or planning a pregnancy in the next four months A personal history of cardiovascular disease; metabolic syndrome, diabetes, or dislipidemia; Bleeding tendency, abnormal bruising or coagulation disorder; Smoker; On medication known to influence lipid or carbohydrate metabolism; Employment in a non-sedentary occupation; Regular participation in more than 150 min of moderate to vigorous physical activity; Contraindications for participating in physical activity Intolerance/Allergy to gluten or dairy
Outcome results
None listed