None listed
Conditions
Brief summary
This project aims to evaluate the effectiveness of a brain stimulation technique referred to as transcranial magnetic stimulation (TMS) in treating obsessive compulsive disorder (OCD). Thirty OCD patients will allocated to either the control or experimental condition and receive TMS once daily for three weeks (Monday to Friday). Patients will then be followed up at two times points; after one week and four weeks post-treatment. The treatment protocol will consist of identifying and stimulating three brain regions which have been shown to be involved in OCD. Each region will be stimulated for 10 minutes using TMS parameters developed within well-established safety guidelines. We will measure the primary and secondary symptoms that patients experience and also measure their ability to perform computerised and pen and paper tasks. It is hypothesised that patients who undergo active treatment will experience a reduction in their OCD symptoms when compared to patients in the control condition.
Interventions
Patients with OCD will receive 15 daily sessions (Monday to Friday) of repetitive transcranial magnetic stimulation over three weeks. Repetitive transcranial magnetic stimulation will be administered using a Magstim Rapidstim system with a 70mm, figure of eight air cooled coil applied to three brain regions sequentially. A fitted cap based on the accepted 10-20 electroencephalography system will be used to identify the three brain regions. The cap will be centred using several landmarks includin
Patients with OCD will receive 15 daily sessions (Monday to Friday) of repetitive transcranial magnetic stimulation over three weeks. Repetitive transcranial magnetic stimulation will be administered using a Magstim Rapidstim system with a 70mm, figure of eight air cooled coil applied to three brain regions sequentially. A fitted cap based on the accepted 10-20 electroencephalography system will be used to identify the three brain regions. The cap will be centred using several landmarks including the distance between the left and right ears (inter-aural distance) and between the bridge of the brow and protrusion in the back of the head (nasion to inion). As the cap is pre-marked, we will be stimulating the left orbitofrontal cortex at coordinate Fp1 using low frequency parameters of 1 Hz using 80% of active motor threshold for 10 minutes (600 pulses), the right dorsolateral prefrontal cortex at the coordinate F4 using high frequency parameters of 10hz for 5 seconds, with an inter-train interval of 25 seconds for 10 minutes (20 trains in total) using 110% of resting motor threshold and the supplementary motor area which will be defined as 15% of the distance between the nasion and inion anterior to the centre point using low frequency parameters of 1Hz at 110% of resting motor threshold for 10 minutes. Overall, patients will be required to attend 40 minute sessions which includes treatment administration and set-up.
Sponsors
Deakin University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Patients with a primary diagnosis of OCD according to the Diagnostic and Statistical Manual of Mental Disorders IV-Test Revision (2000) criteria.
Exclusion criteria
Patients are to be excluded if they have metal implants in or around the head, implanted pace maker or pace maker like devices, metal clips or shrapnel inside the head, if the patient has a past history of epilepsy/seizures, pregnant females and patients who have concurrent psychotic symptoms.
Outcome results
None listed