None listed
Conditions
Brief summary
In this study, the effect of sugammadex, a recently introduced alternative to traditional decurarization by cholinesterase inhibitors, on adrenal cortical hormones has been examined. After local ethics committee approval were obtained and written informed patient consent will obtain, a total of 50 male patients between 18 and 45 years of age with an ASA (American Anesthesiology Association) class of I or II undergoing elective lower extremity surgery with an expected surgery time of 1 to 3 hours will include in this study. Prior to surgery, patients will categorize into two groups (neostigmin group, Group N; and sugammadex group, Group S). In addition to standard monitorization, train-of-four (TOF ) is going to used to monitorize the level of neuromuscular blockade. Standard induction (propofol, rocuronium, remifentanyl) and maintenance (seovoflurane, O2) of anesthesia will perform. At the termination of surgery, neuromuscular blockade will antagonise using 0.05 mg/kg of neostigmine and 0.01 mg/kg of atropin in Group N and using 4 mg/kg sugammadex in Group S when spontaneous recovery of neuromuscular blockade occurs with the reappearance of T2. A total of three blood samples, just before and 15 minutes and 4 hours after antagonism, will obtain in each patient to determine serum aldosterone, cortisol, progesterone, and free testosterone levels.
Interventions
A total of 50 male patients between 18 and 45 years of age with an ASA (American Anesthesiology Association) class of I or II undergoing elective lower extremity surgery with an expected surgery time of 1 to 3 hours were planned to be in this study. Prior to surgery, patients are going to class into two groups (neostigmin group, Group N; and sugammadex group, Group S). In addition to standard monitoring, train-of-four (TOF) is going to use to monitor the level of neuromuscular blockade. Standard
A total of 50 male patients between 18 and 45 years of age with an ASA (American Anesthesiology Association) class of I or II undergoing elective lower extremity surgery with an expected surgery time of 1 to 3 hours were planned to be in this study. Prior to surgery, patients are going to class into two groups (neostigmin group, Group N; and sugammadex group, Group S). In addition to standard monitoring, train-of-four (TOF) is going to use to monitor the level of neuromuscular blockade. Standard induction (propofol, rocuronium, remifentanyl) and maintenance (seovoflurane, O2) of anesthesia will be performed. At the termination of surgery, neuromuscular blockade will be antagonised using 0.05 mg/kg of neostigmine (intravenous injection) and 0.01 mg/kg of atropin (intravenous injection) in Group N and using 4 mg/kg sugammadex (intravenous injection) in Group S when spontaneous recovery of neuromuscular blockade occurs with the reappearance of T2. A total of three blood samples, just before and 15 minutes and 4 hours after antagonism, will be obtained in each patient to determine serum aldosterone, cortisol, progesterone, and free testosterone levels.
Sponsors
Firat University Scientific Research Projects Unit
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Elective lower extremity surgery undergone general anesthesia ASA I-II Male patient 18-45 years of age expected surgery time is 1-3 hours
Exclusion criteria
ASA III, IV and V neuromuscular disease endocrin disease psychiatric, liver, kidney, heart diseases, diabetes mellitus and peripheral neuropathic diseases, co-operation difficulties, difficult intubation possibility, steroid or hormone therapy, obesity (body mass index> 30 kg/m2), neuromuscular blockers interact with drug use (such as magnesium)
Outcome results
None listed