Retinal blood vessels in sleep apnea patients

Retinal vascular complications in obstructive sleep apnea patients

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000475640

Acronym

N/A

Enrollment

100

Registered

2014-05-07

Start date

2014-05-19

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Obstructive sleep apnea (OSA) is a condition consisting of intermittent upper airway obstruction during sleep, leading to periods of hypoxia (reduced oxygen levels) and acute hypertension (high blood pressure). It has been hypothesized that in OSA, physiological changes can result in retinal ischemia (restriction in blood supply to tissues) and associated retinal vascular changes and progression of glaucomatous damage to the optic nerve. In a previous study, we did not find an increased prevalence of optic disc edema or other optic neuropathies in the OSA population. However, retinal vascular changes were more common in patients with severe OSA, independent of blood pressure, suggesting that OSA patients should undergo ophthalmologic screening. Despite this, the risk for various ocular disorders among patients with OSA remains unclear, particularly because in prior studies only static (single) measures of retinal vessels were considered. Additionally, these studies did not adequately control for potential confounders of these associations, such as obesity and hypertension. The aim of the current study is to investigate dynamic (real time videos) retinal vasculature characteristics in OSA patients and determine any associated changes of the retina in this group of patients. This will provide a new-insight into specific OSA related changes in the eye.

Interventions

Non-invasive optical scanning of the retina. This will take approximately 15 minutes and will be a one-off scan.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. OSA patients undergoing overnight diagnostic polysomnography will be included 2. Gender: M/F 3. Age range: 18+ 4. Clear ocular media with visual acuity >= 6/12. 5. Not on previous ocular study trial.

Exclusion criteria

1. Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study. 2. Participants with a history of ocular disease(s) that are likely to interfere with the metabolism or excretion of test medications. 3. Participants with a history of a psychological illness or other conditions which may interfere with their ability to understand the study requirements.

Outcome results