The effect of dietary fats on appetite and metabolism

The effect of dietary fats on the postprandial appetite and metabolism response in overweight healthy men aged 18-40 years old.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000466640

Enrollment

Registered

2014-05-05

Start date

2014-05-14

Completion date

2014-12-03

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project aims to understand the effect of high saturated fat meals differing in saturated fatty acid chain length on energy expenditure and fat metabolism. Evidence suggests that not all fats are metabolised in the same way and not necessarily equivalent in the way they behave to maintain energy balance in the body. Ingesting fats that have a propensity to increase biological energy expenditure, fat oxidation and fullness may ultimately have beneficial effects on body weight control. It is postulated that individuals will find it easier to make changes in the types of fat they eat rather than total amount of fat when aiming to control body weight, especially in adulthood when dietary preferences can already be quite ingrained.

Interventions

The intervention will be two high saturated fat muffins (40% total fat of which 50% is saturated fat) differing in saturated fatty acid chain lengths. One muffin will be higher in long chain saturated fatty acids (99% long chain and 1% short chain) and one will be lower in long chain saturated fatty acids (70% long chain and 30% short chain). The total grams of fat will be approximately 46grams.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject)

Eligibility

Sex/Gender

Male

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Male aged 18-40 years old BMI 27kg/m2 - 35kg/m2 if you are Caucasian; or BMI 25kg/m2 to 30kg/m2 if you are Asian/Indian Waist Circumference more than 102 cm if you are Caucasian, or more than 92 cm if you are Asian/Indian Weight stable (within +/-2kg in the last 6 months) Non-smoker Fasting blood glucose levels less than 6.0mmol/L Fasting triglyceride levels less than 3.0 mmol/L Fasting cholesterol less than 6.0mmol/L

Exclusion criteria

Taking any medications known to alter body composition or metabolism e.g. thyroxin, glucocorticoids Obesity due to secondary causes relating to genetic or endocrinology related disorders Lactose intolerant or vegetarian Diagnosed with, and or on drug therapy for diabetes, high blood pressure, high cholesterol or cardiovascular disease

Outcome results