Urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion and Renal Functions in Mild Maternal Hydronephrosis

Evaluation of the Outcomes of Renal functions and Urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion in Mild Maternal Hydronephrosis and normal pregnancies

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000455662

Enrollment

Registered

2014-05-01

Start date

2014-05-19

Completion date

2015-03-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein of the lipocalin superfamily. NGAL was identified in neutrophils and is expressed in many tissues, including adipocytes, bone marrow, uterus, stomach, colon, lung, liver, and kidney. This is especially seen in response to renal tubular injury, and NGAL appears so rapidly in the urine and serum that it is useful as an early biomarker of renal failure. Objective of the study is to assess the renal functions and urinary NGAL levels in pregnants with or without mild maternal hydronephrosis. Approximately 100 subjects will be included in this study. Cases with mild hydronephrosis will be included as study group and remaining normal subjects will be included as control group. Urinary NGAL levels and other renal functions will be compared between groups using statistical methods following completion of all medical records.

Interventions

A total number of approximately 100 pregnant cases will be included in this prospective study. Subjects will be divided into 2 arms according to their urinary ultrasonographic findings between 24-36th week of their pregnancies. Pelvic-calyceal complex in millimeters from leading edge to leading edge, in two dimensions less than 5mm will be included in control arm, whereas dimensions between 5-15mm will be included in study arm as mild hydronephrosis cases. Urinary neutrophil gelatinase-associate

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

singleton pregnancies between 24-36 weeks of gestation without identifiable maternal and fetal disorders other than maternal hydronephrosis.

Exclusion criteria

-Active urinary tract infection -urolithiasis -known genitourinary anomalies -gestational or nongestational diabetes mellitus -preeclampsia -chronic hypertension -chronic kidney or liver diseases -chronic vascular or connective tissue diseases The well-being of the fetus and the pregnancy was established with a biophysical profile scoring. Pregnancies with a jeopardized fetus, Bishop score over four, or active labor were excluded.

Outcome results