None listed
Conditions
Brief summary
Conditions of temporary glucose intolerance - such as gestational diabetes - identify people who are at risk from subsequently developing type 2 diabetes. This is important as the prompt diagnosis of glucose intolerance allows earlier treatment and a consequent reduction in complications associated with prolonged and untreated hyperglycaemia, dyslipidaemia and hypertension. The possibility that critical illness-associated hyperglycaemia (CIAH) could be a risk factor for subsequent type 2 diabetes has only been evaluated in one study. This study however has substantial limitations, which severely restrict interpretation of these data. If CIAH is a risk factor for development of type 2 diabetes, and the mechanisms underlying any glucose intolerance elucidated, survivors could be screened for diabetes and prompt appropriate therapy instituted.
Interventions
Blood test (HBA1c & Fasting Lipids), Oral Glucose tolerance test , Isotope breath test and height, weight and blood pressure will be measured at 3 months, 1, 2, 3, 6 and 10 years of health and unhealthy volunteers.
Sponsors
Dr Adam Deane
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Critical Illness-associated hyperglycaemia: HbA1c < 6.5%, blood glucose concentrations > 11.1 mmol/l for at least two consecutive readings during ICU admission Normoglycaemic: HbA1c < 6.5%, fasted blood glucose concentrations remain < 7.1mmol/l and random concentrations remain < 11.1 mmol/l throughout ICU admission Healthy volunteers: >18 years of age, sex and BMI will be used to match volunteers
Exclusion criteria
Inability to give informed consent, current pregnancy, previous gestational diabetes, acute or chronic pancreatitis, medications known to affect glucose metabolism (e.g. steroids)
Outcome results
None listed