Dietary fructose consumption and cardio-metabolic health

Dietary fructose increases blood lipids and inflammation and reduces insulin response and satiety hormones in healthy volunteers.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000431628

Enrollment

Registered

2014-04-29

Start date

2013-03-12

Completion date

2013-06-24

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

There is evidence in the published literature that consumption of a high fructose diet is detrimental to cardio-metabolic health. The purpose of this research is to determine the effect of dietary fructose consumption on plasma lipids, satiety hormones, insulin resistance and inflammation. If our hypothesis is validated, dietary strategies can be designed to reduce body weight and associated risk for the development of diabetes and cardiovascular disease

Interventions

A dietary intervention acute trial will be conducted in healthy subjects, in randomized controlled cross-over design. Acute trial will involve dietary intervention with a single dose of sugar (fructose/glucose/sucrose) sweetened drink followed by collection of blood samples at 0, 30, 60, and 120 minutes following consumption of a) lemon-flavoured drink containing 50g of fructose, b) lemon-flavoured drink containing 50g of glucose and c) lemon flavoured drink containing 50g of sucrose. After a 1 week period of wash out the experiment will be repeated swapping groups. Subjects will be asked to fill a medical and a physical activity questionnaire and will have their anthropometric measurements taken. In addition, subjects will complete a 24 hour food record.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy male or female. Are aged above 18 years at initial assessment

Exclusion criteria

Currently on cholesterol lowering drugs Currently on non-steroidal anti-inflammatory drugs Currently on fructose/sugar restricted diet Currently on weight loss program Have a body mass index (BMI) greater than 30 Diagnosed with any gastrointestinal disorder Diabetes Pregnancy or lactation Vegan diet Undergone any surgical procedure for obesity

Outcome results