None listed
Conditions
Brief summary
To assess the effectiveness of butyrylated high amylose maize starch (HAMSB) in reducing gastrointestinal symptoms in volunteers suffering a functional bowel disorder. Aim 1: The primary aim is to determine if ingestion of HAMSB reduces symptoms in subjects that suffer a functional bowel disorder HAMSB. Aim 2: The secondary aim is to determine the effect of HAMSB on blood inflammatory markers and faecal microbiota in subjects suffering a functional bowel disorder.
Interventions
Treatment interventions were dietary butyrylated high amylose maize starch (HAMSB) or low amylose maize starch (LAMS) which were consumed daily for 14 days, The starch supplement (HAMSB or placebo starch) consisted of two pre-packed 20 g sachets daily, one consumed in the morning and one in the evening. The supplements were consumed by mixing the starches into 250 mL reduced fat flavoured UHT milk, orange juice, water or foods by the participants. The first intervention was followed by a washout period of 4 weeks during which the participants did not consume any intervention and ate their normal diets. The washout was followed by 2 weeks consumption of the alternative intervention. All unused sachets were collected to monitor compliance, and SCFA levels will be measured in the stools of subjects to further verify compliance to the test starches.
Sponsors
Study design
Eligibility
Inclusion criteria
Medically diagnosed with a functional bowel disorder
Exclusion criteria
1. Constipation is only symptom 2. Intolerant to high fibre products 3. Celiac disease 4. Previous abdominal surgery 5. Diabetes 6. Use of antibiotics for 2 months prior to the commencement of the trial 7. Using anti-diarrhoeal drugs 8. Pregnant or breast feeding, or intending to become pregnant during the study