The effect of zopiclone on the respiratory arousal threshold in obstructive sleep apnoea

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000364673

Enrollment

Registered

2014-04-07

Start date

2014-04-15

Completion date

2014-09-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this physiology study is to determine the effects of zopiclone (sedative) on the awakening (arousal) response to respiratory stimuli during sleep and on upper airway muscle activity and breathing during sleep.

Interventions

Zopiclone (7.5mg), once only immediately before going to bed, taken orally. 1 week washout

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Men and women with obtructive sleep apnoea

Exclusion criteria

-Known allergy or previous adverse reaction to zopiclone -Pregnant or nursing mothers -Patients with any other medical condition which may interfere in the evaluation of the study - Patients taking medications known to affect sleep or muscle activity

Outcome results