None listed
Conditions
Brief summary
Critically ill patients suffer from catabolism, i.e. protein loss, which may contribute to complications such as muscle weakness, protracted ventilator treatment, and delayed recovery. Appropriate feeding may alleviate catabolism, but ideal feeding strategies are controversial, partly because the underlying physiology is poorly understood. We investigate the effect of protein feeding via nasogastric feeding tube in critically ill patients. Using stable isotope techniques, we measure whether whole-body protein catabolism is improved after initiation of feeding.
Interventions
Enteral feeding is initiated in critically ill patients. Due to tolerance problems that are common in these patients, a low dose of enteral nutrition is given initially. At an infusion rate of 20 ml/h, nutrient supply is 0.73 g/h casein and 2.73 g/h maltodextrin. Study nutrition contains casein intrinsically labeled with L-[1-13C]-phenylalanine (van Loon, L.J., et al., J Dairy Sci, 2009. 92:4812-22). This allows measurement of the dietary contribution to whole-body protein kinetics. Measurements
Enteral feeding is initiated in critically ill patients. Due to tolerance problems that are common in these patients, a low dose of enteral nutrition is given initially. At an infusion rate of 20 ml/h, nutrient supply is 0.73 g/h casein and 2.73 g/h maltodextrin. Study nutrition contains casein intrinsically labeled with L-[1-13C]-phenylalanine (van Loon, L.J., et al., J Dairy Sci, 2009. 92:4812-22). This allows measurement of the dietary contribution to whole-body protein kinetics. Measurements of whole-body protein kinetics are made before and after six hours of enteral feeding.
Sponsors
Prof Olav Rooyackers
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
ICU patients who are tracheally intubated or tracheostomized; clinical indication for inititating enteral feeding
Exclusion criteria
Prior enteral feeding; milk protein allergy; ongoing renal replacement therapy or other extracorporeal blood treatment; liver failure; ongoing hemorrhage requiring transfusion; major surgery during the study period; contraindications to enteral feeding via nasogastric tube
Outcome results
None listed