None listed
Conditions
Brief summary
This observational study will track allopurinol and oxypurinol serum concentrations in haemodialysis patients with allopurinol-treated gout across a 48 hour period in order to determine the pharmacokinetics of oxypurinol (the active metabolite of allopurinol) in this particular population. The results will provide insight on the efficacy of current allopurinol dosing strategies in patients with gout on haemodialysis.
Interventions
Patients with gout already receiving 100mg of allopurinol will be recruited from the haemodialysis unit. They will be observed over a 48 hour period that includes one dialysis cycle and two allopurinol dose intervals. On the first day, blood samples will be taken hourly prior to, during, and post-dialysis up until the first 100mg dose of allopurinol. The first blood sample will be taken directly prior to the start of dialysis and then will be taken hourly for 6 hours. The allopurinol will be tak
Patients with gout already receiving 100mg of allopurinol will be recruited from the haemodialysis unit. They will be observed over a 48 hour period that includes one dialysis cycle and two allopurinol dose intervals. On the first day, blood samples will be taken hourly prior to, during, and post-dialysis up until the first 100mg dose of allopurinol. The first blood sample will be taken directly prior to the start of dialysis and then will be taken hourly for 6 hours. The allopurinol will be taken directly following the last blood sample (6 hours after the start of dialysis). On the second day, a second 100mg dose of allopurinol will be given and eight blood samples will be taken at set intervals throughout the day. The first sample will be taken prior to the allopurinol dose, and the remaining samples will be taken 30 minutes, 1 hour, 1.5 hours, 2 hours, 4 hours, and 6 hours after the allopurinol dose. A final blood sample will be taken at 48 hours (post study commencement).
Sponsors
Professor Lisa Stamp
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients must be receiving haemodialysis, must be diagnosed with gout, and must be already receiving 100mg of allopurinol daily.
Exclusion criteria
No exclusion criteria.
Outcome results
None listed