None listed
Conditions
Brief summary
The increased risk of adverse pregnancy outcome is related to glycaemic control, which can be monitored by glycated haemoglobin (HbA1c). HbA1c can identify the average blood glucose concentration over the previous months prior to the measurement. The correlation between HbA1c levels and clinical outcomes depends on appropriately-defined reference intervals, which have not been defined in Hong Kong pregnant women. Fructosamine can also be useful in monitoring the effectiveness of therapy in diabetes, in a manner analogous to the HbA1c. It reflects the glycaemic control over the past 2 – 3 weeks. Therefore it can determine the effectiveness of gestational diabetes mellitus (GDM) treatment earlier compare with HbA1c, which may improve pregnancy outcome in patients with GDM. However, there is only limited experience in use of fructosamine in patients with GDM. Therefore, there is a need to establish trimester-specific reference intervals of HbA1c, fructosamine and fasting blood glucose in non-diabetic pregnant women in the local population, which may be useful in guiding treatment for GDM and diabetes mellitus in pregnancy.
Interventions
To determine the trimester-specific reference intervals for HbA1c, fructosamine and fasting glucose in non-diabetic pregnant women, serum samples will be collected once per trimester.
In order to minimize inconvenience to subjects, serum sample collection in first trimester will be done at the time of first trimester Down screening. Serum sample collection in second trimester will be done at the time of oral glucose tolerance test. Serum sample collection in third trimester will be done at 34 –
To determine the trimester-specific reference intervals for HbA1c, fructosamine and fasting glucose in non-diabetic pregnant women, serum samples will be collected once per trimester. In order to minimize inconvenience to subjects, serum sample collection in first trimester will be done at the time of first trimester Down screening. Serum sample collection in second trimester will be done at the time of oral glucose tolerance test. Serum sample collection in third trimester will be done at 34 – 37 weeks gestation during antenatal visit, together with serum sample collection for other purpose if possible.
Sponsors
Dr Lee Hui Ling Helena
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
Yes
Inclusion criteria
Non-diabetic pregnant women who attend the first trimester Down screening (at 11 to 13+6 weeks gestation) in Queen Elizabeth Hospital, Hong Kong Patients who signed written informed consent in Chinese or English version
Exclusion criteria
Patient with pre-existing diabetes mellitus Patient refusal Inability of patient to give informed consent
Outcome results
None listed