None listed
Conditions
Brief summary
Already known about fibre and ulcerative colitis is that a) Fibre intake goals not achieved by patients with ulcerative colitis b) Gut microbiota differ in patients with ulcerative colitis from healthy people c) Dietary management of ulcerative colitis is not well established New Findings are that a) Patients with inactive ulcerative colitis often have reduced ability to ferment fibre b) Supplementation with fibre as a combination of resistant starch and wheat bran-associated non-starch polysaccharide is well tolerated in patients with ulcerative colitis in remission c) Supplementation with this fibre combination tends to normalise gut transit, but does not increase the proportion of dietary fibre fermented d) Diminished fermentation is not related to rapid gut transit, but more likely resides in the abnormal microbiota Impact on future clinical practice a) The effects of dietary manipulation directed at changing colonic physiology and/or gut microbiota in healthy subjects cannot be extrapolated to patients with ulcerative colitis b) Supplementation with a combination of resistant starch and wheat bran in patients with ulcerative colitis may have some benefits to colonic physiology and health
Interventions
Dietary fibre was supplemented into the habitual diet for two intervention periods of 17 days each. The supplements were introduced at 25% of full dose and incrementally increased to the total dose over 3 days. This was to reduce the risk of gut symptoms to improve compliance.
Arm 1
Fibre added into provided food, at low doses consisting of
2-5 g resistant starch and 2-5 g of wheat bran fibre
Arm 2
15 g resistant starch and 12 g wheat bran fibre.
There was a wash out period of 14 days between i
Dietary fibre was supplemented into the habitual diet for two intervention periods of 17 days each. The supplements were introduced at 25% of full dose and incrementally increased to the total dose over 3 days. This was to reduce the risk of gut symptoms to improve compliance. Arm 1 Fibre added into provided food, at low doses consisting of 2-5 g resistant starch and 2-5 g of wheat bran fibre Arm 2 15 g resistant starch and 12 g wheat bran fibre. There was a wash out period of 14 days between intervention arms. Compliance was measured and monitored with food intake diaries, check lists and returned food items.
Sponsors
Sally James
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age over 18 years Diagnosis of ulcerative colitis, in remission Healthy control inclusion criteria were age over 18 yrs, absence of bowel disease and absence of medication which affect bowel function and microbiota
Exclusion criteria
Diagnosis of Crohn's disease, colectomy Use of any of the following medication within the preceding 4 weeks, due to their effect on bowel and or microbial function: Sulfasalazine, antibiotics, laxatives, topical rectal therapy, codeine or constipating drugs.
Outcome results
None listed