None listed
Conditions
Brief summary
Peanut allergy is increasingly common, especially in countries such as Australia and to date no safe and effective therapy exists to cure peanut allergy. Recently studies have looked at desensitising people with peanut allergy by giving them small daily doses of roasted or raw peanut. Although this therapy works for some people, its effects are not generally long lasting and it is associated with many side effects. It is possible that boiled peanut is less immunogenic than roasted peanut and it may provide a safer way to desensitise patients who are allergic to roasted peanut by desensitising them first to boiled peanut.
Interventions
Following double blind oral food challenges (DPBPFC) to boiled and roasted peanut and placebo, peanut allergic children aged 5-16 years will undergo randomisation to 3 arms of 12 months of treatment with 1. Increasing doses of boiled peanut daily commencing at 0.5 grams. 2. Increasing doses of roasted peanut daily commencing at 0.5 gram.
For arms 1 and 2- Induction phase with updosing over 6 months and further 6 months maintenance (8g) daily. Updosing under supervision. Peanut preparations supp
Following double blind oral food challenges (DPBPFC) to boiled and roasted peanut and placebo, peanut allergic children aged 5-16 years will undergo randomisation to 3 arms of 12 months of treatment with 1. Increasing doses of boiled peanut daily commencing at 0.5 grams. 2. Increasing doses of roasted peanut daily commencing at 0.5 gram. For arms 1 and 2- Induction phase with updosing over 6 months and further 6 months maintenance (8g) daily. Updosing under supervision. Peanut preparations suppled to parents for daily home administration between updosing and during maintenance. Compliance by daily diary. Arm 3. No treatment (delayed start) to cross over at 12 months to boiled peanut OIT as per arm 1 following further DBPCFC. Children roasted allergic/boiled tolerant will proceed directly to daily boiled peanut maintenance at 8g over 12 months.
Sponsors
Professor Dianne E Campbell
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
5 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
Double blind placebo controlled challenge proven roasted peanut allergy at study commencement
Exclusion criteria
unable to undertake study requirments
Outcome results
None listed