Maternal cardiovascular indices in early pregnancy

A study comparing maternal cardiovascular indices of women with healthy early pregnancies (<12 weeks gestation) and those with spontaneous fetal demise.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000241639

Enrollment

Registered

2014-03-06

Start date

2014-03-10

Completion date

2015-02-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this observational prospective cohort study is to compare maternal cardiovascular indices of 20 women with healthy early pregnancies (8-11 weeks gestation) with that of 20 women who have experienced spontaneous miscarriages, to see if there is a difference in systemic vascular resistances (SVR) [the primary outcome of interest]. This information will help in our understanding of a subset of women’s possible causes for miscarriages in early pregnancy, as prior research indicates that some women may have higher SVR and abnormal adaptations to normal pregnancy.

Interventions

Maternal cardiovascular indices eg. cardiac output (CO)and systemic vascular resistances (SVR)of 20 women with spontaneous miscarriages <12 weeks,will be recorded non-invasively using a continuous wave Doppler ultrasound probe placed at the suprasternal notch to insonate the velocity of blood flow through the aortic valve, using the USCOM cardiac output monitor (USCOM Ltd. Sydney, Australia). This will take approximately 1 minute.

Eligibility

Sex/Gender

All

Age

21 Years to 50 Years

Healthy volunteers

Inclusion criteria

Twenty ASA I- II patients scheduled for elective pregnancy terminations between 8-11 gestational weeks, and 20 women with spontaneous miscarriages of <12 weeks' gestation who are scheduled for surgical uterine evacuation.

Exclusion criteria

ASA physical status III- IV, BMI > 40 kg/m2, aged <21 or > 50years, and those with significant pre-existing cardiovascular disease pre-pregnancy eg hypertension, ischaemic heart disease, valvular heart disease, cardiomyopathy.

Outcome results