Investigation of the effects of anaesthetic choice on ventilation-perfusion scatter and lung gas exchange.

A parallel group randomised comparison study of the effects of TIVA propofol versus inhalational sevoflurane anaesthesia on lung ventilation-perfusion matching and gas exchange, in patients undergoing general anaesthesia for surgery requiring relacant GA with an arterial line for cardiovascular monitoring.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000226606

Enrollment

Registered

2014-03-04

Start date

2015-02-02

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The relative effects on V/Q matching in the lung of modern inhalational anaesthetics such as sevoflurane have not been compared with those of the intravenous agent propofol. There are potentially important implications for the management of patients with reduced lung function undergoing surgery.

Interventions

Total intravenous anaesthesia with propofol, titrated against depth of anaesthesia measured using bisepectral index (BIS 40-60).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

Patients undergoing general anaesthesia for surgery requiring relacant GA with an arterial line for cardiovascular monitoring.

Exclusion criteria

Severe impairment of lung function. (FEV1 or FVC less than 30% predicted), or morbid obesity (Body mass index (BMI) greater than 40 kg/m2)

Outcome results