Use of glucose to assist fructose absorption in various forms to eliminate symptoms in Irritable Bowel Syndrome (IBS) fructose malabsorbers

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000176662

Enrollment

Registered

2014-02-12

Start date

2013-08-26

Completion date

2014-03-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Our research team has identified dietary triggers that might be responsible for the induction of symptoms in the majority of patients with IBS. These triggers involve a group of small carbohydrates that are commonly found in a wide variety of foods. These carbohydrates can be poorly absorbed in the small intestine and include; fructose (in apples, pears and fruit juice), lactose (milk), fructans (onions), galacto-oligosaccharides (legumes) and sugar alcohols (stone fruits and artificial sweeteners). We have named this group of compounds FODMAPs - Fermentable Oligo- Di- and Mono-saccharides And Polyols. There is already good evidence that the absorption of one of these FODMAPS; fructose, is greatly enhanced in the presence of glucose. However there is no data investigating this absorption method in IBS sufferers, specifically whether the addition of glucose to fructose eliminates symptoms. We hypothesize that the addition of glucose will reduce breath hydrogen production and reduce gastrointestinal symptoms.

Interventions

Breath hydrogen production and symptoms will be measured after drinking 6 different sugar solutions over 6 days (separated by at least 1 day in between, depending on symptoms). The sugar solutions will be made up to 375ml with water, the sugars tested will include: *Glucose- 50g in 375ml *Sucrose- 50g in 375ml *Fructose- 25g in 375ml *Fructose- 25g + Glucose- 25g in 375ml *Fructans- 10g in 375ml *Fructans- 10g + Glucose- 25g in 375ml

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

- Malabsorb a 35g dose of fructose with a breath hydrogen rise of above 15ppm from baseline considered a positive result, with results being no more than 3 months old. If results were older than this they were retested. - Have a functional gastrointestinal disorder OR have no significant gastrointestinal symptoms,

Exclusion criteria

- Other gastrointestinal disease (e.g., Crohn’s, Ulcerative colitis, Coeliac) or diabetes - Pregnant or breastfeeding. - Can not have taken antibiotics, probiotics or had colonoscopy preparation in the past 2 weeks.

Outcome results