Efficacy of oral sucrose in newborns exposed to painful stimuli

Efficacy of 24% oral sucrose in the prevention and treatment of pain in Neonatal Intensive Care Unit

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000164695

Enrollment

Registered

2014-02-11

Start date

2013-06-01

Completion date

2013-08-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is aimed to investigate, using skin conductance algesimeters index monitor pain, the effects of 24% sucrose solution and non nutritive sucking on pain perception during capillary and arterial blood sample taking. Skin conductance algesimeters reflects the sympathetic nervous system influenced by changes in emotions which releases the acetyl choline that acts on muscarine receptors, causing a subsequent burst of sweat and increased skin conductance.

Interventions

Arm1: 24% sucrose oral solution was administered during capillary and arterial blood sample taking, directly by a disposable plastic vial at dosage of 1.5 ml for newborns with more than 3 kg and 1 ml for newborns with a birth weight less than 3 kg

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to 1 Months

Healthy volunteers

Inclusion criteria

All infants admitted to the Unit of Neonatal Intensive Care of Monaldi Hospital, Naples, Italy.

Exclusion criteria

Newborns receiving muscle relaxants and those with impaired skin integrity, which precluded applying additional tape or monitoring devices to the skin.

Outcome results