A study to estimate the changes in serum periostin levels in adult patients, following dental extractions with or without surgery.

A study to estimate the magnitude and time course changes in serum periostin levels in adult patients, following either simple tooth extraction, or tooth extraction involving surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000152628

Acronym

PER05

Enrollment

Registered

2014-02-07

Start date

2015-03-03

Completion date

2016-08-22

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Levels of POSTN (a protein-coding gene, also known as osteoblast specific factor) gene expression and periostin have been measured in a number of tissues and disease states. Periostin is associated with type I collagen in the periodontal ligament where it regulates the biomechanical properties of connective tissue around the tooth. Increased expression of the POSTN gene has been measured in the periodontal ligament on occlusal loading, investigators concluding that periostin is therefore essential for the integrity and function of the ligament. The serum levels of periostin following dental surgery have not yet been investigated. This study of the magnitude and longitudinal changes in serum periostin levels in participants undergoing dental surgery endeavours to determine the clinical significance of periostin following dental surgery. Results from this study will provide a clearer picture of periostin production and further the development of periostin as a serum biomarker for asthma, as part of a programme of research being conducted at the Medical Research Institute of New Zealand.

Interventions

Serum Periostin levels Serum Periostin levels will be measured at 7 time points: Baseline (up to 1 week prior to tooth extraction/surgery), Week 1, Week 2, Week 3, Week 4, Week 6 and Week 12 post extraction, via a specific periostin laboratory assay.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

Aged between 18 to 75 years Able to provide informed consent Scheduled for dental extraction +/- surgery

Exclusion criteria

Doctor’s diagnosis of Asthma, Bronchitis or COPD Wheezing or use of respiratory inhalers in the past 12 months Known pregnancy Significant co morbidities (determined at investigator discretion) Hospital admission within last 3 months Surgery within last 3 months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc). Oral or Systemic Corticosteroids within the last 3 months Any other safety concern at the investigator’s discretion

Outcome results