Comparison of frusemide alone and frusemide and Indapamide on sodium excretion and balance in fluid overloaded Intensive Care Unit (ICU) patients

Comparison of frusemide alone and frusemide and Indapamide on sodium excretion and balance in fluid overloaded Intensive Care Unit (ICU) patients.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000145606

Enrollment

Registered

2014-02-05

Start date

2013-11-04

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A prospective randomized clinical trial to compare the urinary sodium excretion in ICU patients with fluid overload treated with frusemide alone when compared with frusemide and Indapamide

Interventions

Effects of orally administered as once only dose of frusemide (0.5-1mg/kg) with indapamide (5mg) on 24 hours urinary sodium excretion in ICU patients with fluid overload

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with fluid overload and indwelling urine catheter

Exclusion criteria

1 Patients on renal replacement therapy 2 Patients with other drains present (for e.g. surgical drains, chest drain) 3 Child C liver disease 4 Patients not expected to survive for next 24 hours or those not for active treatment based on the treating consultant opinion 5 Patients on regular diuretics 6 Patients with chronic renal disease with baseline Creatinine > 180 umol/L 7 Sulphonamide allergy 8 Lactose intolerant 9 Suspected or confirmed pregnancy

Outcome results