Effects of intravenous caffeine on Fractional Flow Reserve measurements in coronary artery disease

To compare fractional flow reserve (FFR) before and after intravenous caffeine administration in coronary artery disease patients to evaluate effect of caffeine on FFR levels

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000142639

Enrollment

Registered

2014-02-05

Start date

2011-12-05

Completion date

2012-06-15

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Intravenous adenosine is used to minimize the coronary micro-resistance to achieve maximal hyperemia along with nitrates for optimal fractional flow reserve (FFR) measurements. We hypothesize that caffeine, being a competitive inhibitor of adenosine, would influence adenosine mediated FFR readings. Consecutive patients undergoing angiogram and FFR measurements were enrolled after abstaining from caffeine for 24 hours. Patients with any contraindications to intravenous adenosine or caffeine were excluded. FFR measurements were taken using nitrates and adenosine pre and post 4mg/kg intravenous caffeine administration and results were compared.

Interventions

Fractional flow reserve measurements performed as clinically required. intravenous caffeine administration 4mg/kg (maximum 400 mg IV) Repeat fractional flow reserve measurements 10 minutes after caffeine administration

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Moderate coronary artery disease requiring FFR measurements. FFR measurement <0.90 Valid consent

Exclusion criteria

Inability to give informed consent Caffeine contraindicated Adenosine contraindicated

Outcome results