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The effectiveness of branched-chain amino acid (BCAA) supplementation in delaying fatigue during prolonged exercise.

In healthy males, does branched-chain amino acid (BCAA) supplementation delay fatigue during prolonged exercise?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12614000136606
Enrollment
18
Registered
2014-02-05
Start date
2014-07-01
Completion date
2014-12-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Fatigue is common during exercise, with fatigue being described as sensations of tiredness with associated decrements in muscular performance and function. Exercise-induced fatigue is unique as it presents acutely and both the perception and duration of fatigue may be manipulated. Studies have shown that at the end of prolonged exercise, the concentration of serotonin was ultimately high compared to before exercising. Although we know the consumption of branched-chain amino acid (BCAA)are able to reduce the concentration of serotonin, there are still discrepancies to prove the effectiveness of BCAA in delaying fatigue and improve performance.

Interventions

The BCAA supplements will be a mix of 7g of BCAA powder and non sugar cordial in 1 liter of water. The amount consumed will be 2ml/kg of body weight for every 15 minutes during prolonged cycling exercise. Participants will have to cycle twice with at least 3 days gap as wash out period and during each session participants will have to cycle as quick as possible to reach pre-determined total energy expenditure which will endure for about 60 - 90 minutes

Sponsors

Murdoch University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender
Male
Age
18 Years to 44 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy males sedentary to recreationally active

Exclusion criteria

Participants with hypertension, asthma, diabetes, bronchitis, anaemia, any injury, heart problems, kidney or liver diseases and or any other major diseases will be excluded.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026