None listed
Conditions
Brief summary
A new test for diagnosis and early detection of endometrial cancer
Interventions
200 Postmenopausal women with one or more episode of vaginal bleeding will be included after signing informed consent.
The transvaginal ultrasonography (TVS ) and uterine fluid sampling for lactate dehydrogenase ( LD ) isoenzyme analysis will be performed as office examinations taking about 30 minutes on the same setting.
Endometrial thickness will be classified as >5 mm or <5 mm on TVS.
Patients with endometrial thickness >5 mm on TVS will be evaluated with diagnostic curettage, and tho
200 Postmenopausal women with one or more episode of vaginal bleeding will be included after signing informed consent. The transvaginal ultrasonography (TVS ) and uterine fluid sampling for lactate dehydrogenase ( LD ) isoenzyme analysis will be performed as office examinations taking about 30 minutes on the same setting. Endometrial thickness will be classified as >5 mm or <5 mm on TVS. Patients with endometrial thickness >5 mm on TVS will be evaluated with diagnostic curettage, and those with endometrial thickness <5 mm will be evaluated with office endometrial biopsy usually within one week . LD isoenzyme profile will subsequently be related to histopathological diagnosis.
Sponsors
alexandria univerisity
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
females with postmenopausal uterine bleeding even one episode of bleeding will be included in the study
Exclusion criteria
Patients with recent endometrial sampling. Current hormone replacement therapy Uterine fluid collection at TVS Clinical signs of endometritis
Outcome results
None listed