A study comparing serum periostin levels in Caucasian and Chinese adult populations without asthma or any other significant respiratory co-morbidity, and comparing serum periostin levels in a Chinese adult population with mild asthma versus moderate/ severe asthma

A study comparing serum periostin levels in Caucasian and Chinese adult populations without asthma or any other significant respiratory co-morbidity, and comparing serum periostin levels in a Chinese adult population with mild asthma versus moderate/ severe asthma.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000122651

Acronym

PER07

Enrollment

188

Registered

2014-01-31

Start date

2015-05-25

Completion date

2015-11-09

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Levels of POSTN (a protein-coding gene, also known as osteoblast specific factor) expression and periostin have been measured in a number of tissues and disease states, and results from studies measuring serum periostin levels have indicated that there may be a difference in serum periostin levels in people of Chinese descent. This study endeavours to provide serum periostin levels in a healthy Chinese population which will then be compared to levels found in healthy Caucasians. Results from this study will be used to determine whether a serum periostin reference range is required for the Chinese population. The study will also look at the periostin levels in Chinese asthmatic patients, in order to determine if there is a difference in periostin levels between Chinese patients with and without asthma.

Interventions

Serum Periostin levels Serum Periostin levels will be measured at a single visit (at enrolment), via a specific periostin laboratory assay.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Between 18 to 75 years of age Able to provide written informed consent Born in New Zealand, Australia, China, Hong Kong, Taiwan, Singapore or other countries in Asia Of Chinese descent, more specifically: Both parents that self-identify as ethnic Chinese Residing in New Zealand for more than one year at Visit 1 For Group 1 (non-asthmatics), at least 10 male and 10 female participants will be recruited to each of the following four age bands; 18-30, 31-45, 46-60 and 61-75 years. For Group 2 (asthmatics), participants will have a current diagnosis of asthma. 34 will have mild asthma (treated with a SABA) and 34 will have moderate/severe asthma (treated with an ICS).

Exclusion criteria

Group 1 Doctor’s diagnosis of Asthma, Chronic Bronchitis or COPD Wheezing or use of respiratory inhalers in the past 12 months Systemic Corticosteroids within the last three months Group 1 and 2 Current smoker, or former smoker with a smoking history of greater than 10 pack-years. Known pregnancy First six weeks post-partum Significant co morbidities (determined at investigator discretion) Hospital admission within last three months Surgery within last three months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc). Bone fracture within the last three months Active (current, or within the three weeks prior to the visit) upper or lower respiratory tract infection Any other safety concern at the investigator’s discretion

Outcome results