Carbetocin versus syntometrine for prevention of postpartum hemorrhage after cesarean section

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000117617

Enrollment

450

Registered

2014-01-30

Start date

2011-06-01

Completion date

2013-05-30

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A double blind randomized study conducted on 450 pregnant subjected randomly either to single 100 microgram IV dose of carbetocin (150 women) or combination of 5 IU oxytocin and 0.2 mg ergometrine (300 women) after fetal extraction and before placental removal to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after Cesarean section

Interventions

single 100 microgram IV dose of carbetocin (Pabal) after fetal extraction and before placental removal

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

37 – 40 weeks of gestational age noncomplicated pregnancy. Cesarean sections are a mixture of planned and emergency interventions under regional anaesthesia

Exclusion criteria

placenta previa coagulopathy preeclamptic known sensitivity to oxytocin or methergine

Outcome results