None listed
Conditions
Brief summary
The aim of this project is to reduce the deaths caused by Heart Failure in Tasmania. This will be achieved through implementation of a screening program for cardiac dysfunction and the use of protective therapy that will limit the development of heart failure. We plan to show the benefit of testing by recruitment of "at risk" subjects from the community and randomising them to a screening program based on echocardiography. Patients with abnormalities will be entered into a program of cardio-protective therapy, supervised by their general practitioner. Endpoints: 6-minute walk at a minimum of 24 months and comparison of the rate of heart failure among groups.
Interventions
Inclusion of myocardial mechanics in screening echocardiography for heart failure. This screening test is envisaged at one point in time and the acquisition takes ~30 minutes.
Sponsors
Menzies Research Institute Tasmania
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Aged >65 years with one or more of the following; - diabetes (T2DM) - obesity - high blood pressure - past cancer chemotherapy - F/H of heart failure - known cardiac disease (but not existing heart failure)
Exclusion criteria
- Unable to provide written informed consent to participate in this study - Participating in another clinical research trial where randomized treatment would be unacceptable - History of >moderate valvular heart disease - History of previous heart failure - Existing medical therapy with beta blockers and ACE inhibitors - Contraindications/Intolerance to beta blockers or ACE inhibitors - Systolic BP <110mmHg - Pulse <60/minute - Baseline NYHA >2 - Oncologic life expectancy < 12 months - Inability to acquire interpretable images (identified from baseline echo)
Outcome results
None listed