A study investigating age and sex specific reference ranges for periostin in a general adult population without asthma or any other significant respiratory co-morbidity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12614000047695

Acronym

PER01

Enrollment

480

Registered

2014-01-17

Start date

2014-01-24

Completion date

2014-07-15

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Levels of POSTN (a protein-coding gene, also known as osteoblast specific factor) expression and periostin have been measured in a number of tissues and disease states but as a reference range of periostin level for a normal population does not exist it is difficult to determine the clinical significance of these measurements. This study endeavours to provide a reference range for serum periostin level to allow comparison to be made of periostin levels in certain disease states against those of a healthy population.

Interventions

Serum Periostin levels Serum Periostin levels will be measured at a single visit (at enrolment), via a specific periostin laboratory assay.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Aged between 18 to 75 years Able to provide written informed consent

Exclusion criteria

Doctor’s diagnosis of Asthma, Bronchitis or COPD Wheezing or use of respiratory inhalers in the past 12 months Known pregnancy Significant co morbidities (determined at investigator discretion) Hospital admission within last 3 months Surgery within last 3 months, determined at investigator discretion (this includes all major surgery requiring general anaesthetic, dental extractions and root canal procedures. This does not include minor procedures, including but not limited to mole or wart removal, dental fillings etc). Bone fracture within the last 3 months Systemic Corticosteroids within the last 3 months Active (current, or within the 3 weeks prior to the visit) upper or lower respiratory tract infection Any other safety concern at the investigator’s discretion

Outcome results