Plant-derived berry extracts and appetite control

Evaluation of hunger, satiety and food intake by comparison of high and low dose plant-derived berry extracts and placebo in a group of 20 healthy male.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000041651

Enrollment

Registered

2014-01-16

Start date

2014-01-18

Completion date

2014-02-28

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Background: Plant-origin berry extract is predicted to be able to activate satiety mechanisms which may suppress both hunger and food intake. Aim: This study aims to measure the effect of encapsulated Plant-origin berry extract consumed with breakfast meal on hunger, appetite and energy intake at a subsequent buffet lunch meal. Design: This will be a high-dose, low-dose and placebo, crossover intervention study comprising 20 healthy lean male subjects (aged 18-60 years) with both researches and participants blinded to treatment. Participants will be given a standard 2 MegaJoules (MJ) breakfast followed 3 hours later by a lunch meal which is consumed ad lib until the participant is comfortably full. Outcome variables will be feelings of hunger, fullness and associated appetite sensations as well as energy and macronutrient intake at the ad lib lunch meals.

Interventions

high dose and low dose plant-derived berry extracts. berry extract is made from Vitis vinifera. dosage is 500mg for low dose and 1500mg for high dose. The berry extracts is only taken once orally. The duration is 1 day for each dose. This is a cross-over study with washout period of minimum 3 days. Participants will be given toast for breakfast along with the berry extracts.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Male Age 18-60 years. Lean (as defined by BMI in the range of 18-28 kg/m2). Healthy, as ascertained by self-report. Desire to participate in clinical trial.

Exclusion criteria

Significant endocrine, cardiovascular, gastrointestinal, metabolic disease or cancer/s including a history of these diseases Any medical conditions known to affect appetite related research parameters. Smokers or ex-smokers who had quit within the previous 6 months. Weight loss/gain of 5kg within the previous 6 months, or taking part in an active diet program such as Jenny Craig, Weight Watchers. Taking medications for weight loss or other conditions known to affect appetite regulation. Depression or any other anxiety disorder known to affect appetite. Hypersensitivities or allergies to any foods or ingredients included in the study. Unwilling/unable to comply with study protocol.

Outcome results