Sequential letrozole and human menopausal gonadotropins (HMG) : The effect of a novel super ovulation protocol on pregnancy rate in polycystic ovarian syndrome patients undergoing intracytoplasmic sperm injection. Randomized Controlled Trial

Sequential administration of letrozole and Human Menopausal gonadotropins (HMG) improves the pregnancy rate in polycystic ovarian syndrome ( PCOS) patients treated with intracytoplasmic sperm injection ( ICSI ) – a randomized controlled trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614000025639

Enrollment

Registered

2014-01-09

Start date

2014-01-15

Completion date

2016-01-08

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

a new induction protocol for polycyctic ovary syndrome patients complaining of inability to concieve that hopefully will lead to improvement of pregnancy rate

Interventions

Induction of ovulation will be done by letrozole tablets 5 mg mg /day from day 2 to day 6 of the participant's menstrual cycle then human menopausal gonadotropins ( HMG ) ampoules (fostimon ;IBSA) ( 150-225 IU /day ) will be given intramuscular according to patients response started from day 7 of menstrual follow till the day of human chorionic gonadotropin (HCG) -which is a hormone similar to endogenous lutienizing hormone to trigger ovulation-in a dose of 10000 iu intramuscular when

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 35 Years

Healthy volunteers

Inclusion criteria

PCOS complaining of infertility age between 20-35 years. normal semen analysis according to WHO criteria

Exclusion criteria

female with a previous history of pelvic surgery endometriosi. females with a previous history of failed ICSI

Outcome results