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A randomised controlled study evaluating the use of water during a colonoscopy in patients to facilitate the performance of the colonoscopic procedure

A randomised controlled study evaluating the use of water during a colonoscopy in patients to facilitate the performance of the colonoscopic procedure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12614000018617
Enrollment
410
Registered
2014-01-07
Start date
2012-08-08
Completion date
2014-03-28
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

CRC is the second leading cause of cancer death, and accounts for approximately 9% of cancer deaths overall. Approximately one in three people who develop CRC die of this disease. Colonoscopy is considered the gold standard for screening but requires time, sedation and patients may experience some discomfort during the procedure. The standard method of colonoscopy uses air to inflate the colon in order for the lumen to be visualized and the instrument to be safely passed to the caecum/terminal ileum. Water assisted colonoscopy has been described to reduce caecal intubation time as well as analgesia requirements. However this technique has not been studied in a wide variety of patients nor in patients typical of a population appropriate for colorectal cancer screening. We aim to investigate the benefit of water assisted colonoscopy to reduce the time of intubation and thereby also allow a reduction in the sedation requirements and overall improve patient experience. We anticipate this will result in reduced procedural times and expense and hence allow more screening to be conducted without adversely affecting patient experience. It is speculated that water may decrease friction and lead to a reduction in intubation time and less cramping from air. To investigate the benefit of water assisted colonoscopy to reduce the time of intubation and thereby also allow a reduction in the sedation requirements and overall improve patient experience

Interventions

The use of room temperature water as an adjunctive method for distension of colon lumen during colonoscopy. Approximately 300ml of sterile water will be instilled into the colon during the colonoscopy procedure. The addition of water will take approximately 2-3 minutes to the overall time of the procedure. Additional gas insufflation (the normal standard of care) will also be used in addition to the water to achieve adequate colon distension to facilitate the procedure. Patients will be random

The use of room temperature water as an adjunctive method for distension of colon lumen during colonoscopy. Approximately 300ml of sterile water will be instilled into the colon during the colonoscopy procedure. The addition of water will take approximately 2-3 minutes to the overall time of the procedure. Additional gas insufflation (the normal standard of care) will also be used in addition to the water to achieve adequate colon distension to facilitate the procedure. Patients will be randomised to either the water assisted group or the standard of care. patients will be blinded to which arm they have been allocated to, but the operator will be unblinded. Standard parameters will be monitored and recorded during the procedure in both arms to assess the effect/difference between the two groups

Sponsors

Division of Gastroenterology, St Michael's Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Age over 18 years of age. Appropriate clinical indication for a colonoscopy

Exclusion criteria

Previous colonic surgery Haemodynamic instability

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026