The effect of perioperative intra-articular magnesium on postoperative pain after shoulder surgery

Is perioperative intraarticular magnesium effective for postoperative analgesia in arthroscopic shoulder surgery?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001360707

Enrollment

Registered

2013-12-12

Start date

2009-11-30

Completion date

2010-07-16

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Magnesium has analgesic properties, primarily related to the antagonism of the N-methyl-o-aspartate (NMDA) receptor and the regulation of calcium influx into cells . This analgesic effect was first demonstrated in humans in 1996 when magnesium was administered intravenously in the peri-operative period . It has been reported to reduce postoperative analgesic requirements . The analgesic efficacy of intraarticular magnesium is evident after knee surgery, but its effect after shoulder surgeries has not been reported in the literature . Thus, the goal of this study is to evaluate the potential analgesic effect of magnesium when injected intraarticularly during arthroscopic shoulder surgery.

Interventions

Group M (Magnesium): Patients (n=30) had 1000 mg magnesium sulphate (100 mg ml-1)intraarticular in 10 ml saline Magnesium administered after completion of the surgery before extubation intraarticularly over 5 minutes.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

The inclusion criteria were participants are scheduled for arthroscopic shoulder surgery who not to have had any analgesic or corticosteroid for preceeding 72 hours, not to have any drug or alcohol addiction, not to be allergic to study drugs, and be able to use patient controlled analgesia

Exclusion criteria

Exclusion criteria included; known allergy to one of the study drugs; major hepatic, renal, or cardiovascular dysfunction, especially atrioventricular block; and prior treatment with opioids and calcium channel blockers.

Outcome results