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The importance of microcirculation and pathophysiological role of endothelin-1 in kidney transplantation

The importance of microcirculation and pathophysiological role of endothelin-1 in kidney transplantation

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12613001358730
Enrollment
20
Registered
2013-12-11
Start date
2014-01-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Twenty patients undergoing kidney transplant will be included in the study. Data regarding preoperative variables, intraoperative and postoperative variables are prospectively collected. A non-invasive device (called Sidestream Dark Field imaging), that allow for clinical observation of the microcirculation will be used. It is hand-held probe with a sterile extension for direct contact with renal parenchyma. kidney biopsies are performed to assess Immunohystochemical intensity of ET-1 and other markers. The tissue to be acquired in this study will be obtained from surgical specimens taken from consented participants having kidney transplant.

Interventions

Twenty patients undergoing kidney transplantation will be included in the study. Data regarding preoperative variables, intraoperative and postoperative variables (delayed graft function, rejection), are prospectively collected. Patients will be followed up for 30 days A non-invasive device (called Sidestream Dark Field imaging), that allow for clinical observation of the microcirculation will be used 30 minutes after kidney reperfusion. It is hand-held probe with a sterile extension for dire

Twenty patients undergoing kidney transplantation will be included in the study. Data regarding preoperative variables, intraoperative and postoperative variables (delayed graft function, rejection), are prospectively collected. Patients will be followed up for 30 days A non-invasive device (called Sidestream Dark Field imaging), that allow for clinical observation of the microcirculation will be used 30 minutes after kidney reperfusion. It is hand-held probe with a sterile extension for direct contact with renal parenchyma. The tissue to be acquired in this study will be obtained from surgical specimens taken from consented participants having renal transplant.

Sponsors

Royal Prince Alfred Transplant Institute
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

patients undergoing kidney transplant

Exclusion criteria

Patients who did not agree to be included in the study

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026