Do nitric oxide donor drugs decrease the incidence of pre-eclampsia in high risk teenagers pregnant for the first time?

Does prophylactic treatment with nitric oxide donor drugs decrease the incidence and severity of pre-eclampsia in high risk teenage primigravidas with uterine artery diastolic notch at 20-24 weeks gestation?

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12613001354774

Enrollment

200

Registered

2013-12-11

Start date

2011-03-01

Completion date

2012-12-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Teenagers primigravidas with uterine artery diastolic notch at 20-24 weeks gestation are considered at high risk for pre-eclampsia and were randomized to a control group received iron supplementation and a study group received iron supplementation plus 20 mg isosorbid mononitrate tablet vaginally once daily with the aim of decreasing the incidence and severity of pre-eclampsia. Both groups received treatment until delivery and were followed by antenatal care.

Interventions

Teenagers primigravidas with uterine artery diastolic notch at 20-24 weeks gestation were randomized to a control group received iron supplementation and a study group received iron supplementation plus 20 mg isosorbid mononitrate tablets once daily applied vaginally until delivery. Both groups were followed by routine antenatal care until delivery. Adherence to treatment was monitored by drug tablet return.

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Eligibility

Sex/Gender

All

Age

16 Years to 20 Years

Healthy volunteers

Inclusion criteria

teenagers primigravidas with normal pregnancy who showed uterine artery diastolic notch at 20-24 weeks gestation.

Exclusion criteria

patients treated with vasodilators

Outcome results