None listed
Conditions
Brief summary
Tear film lipid layer plays an important role in maintaining tear film stability and ocular comfort. Contact lens wear compromises ocular surface equilibrium by disrupting the lipid layer which results in lens related ocular dryness and discomfort. The troublesome symptom of the contact lens wear often leads to discontinuation of lens wear and hence is critical for the researchers to design ways to overcome the challenge. Artificial tear supplements have been used to increase ocular comfort. This study aims to understand tear film lipids of contact lens wearers and also to evaluate the effect of exogenous lipid supplements on different aspects of tear film lipid layer. Hypotheses: 1. Improved contact lens comfort is associated with a thicker lipid layer and decreased lipid degradation resulting in reduced tear evaporation. 2. Use of an exogenous tear lipid supplement increases lipid thickness, reduces lipid degradation, increases tear stability, reduces tear evaporation and consequently improves contact lens comfort.
Interventions
There are two interventions used.
1. A phospholipid emulsion drop (Systane Balance, Alcon)
2. A phospholipid liposomal spray (Tearsagain, Biorevive)
All participants will use both interventions and placebos during the study period which is 4 separate phases (4 x 14 days). The dose used for drop is 0.05 ml thrice daily for 14 days and for spray is 0.05 ml thrice daily for 14 days. The drop is applied directly to the eye with contact lens wear and the spray is sprayed on to the closed eyelid ma
There are two interventions used. 1. A phospholipid emulsion drop (Systane Balance, Alcon) 2. A phospholipid liposomal spray (Tearsagain, Biorevive) All participants will use both interventions and placebos during the study period which is 4 separate phases (4 x 14 days). The dose used for drop is 0.05 ml thrice daily for 14 days and for spray is 0.05 ml thrice daily for 14 days. The drop is applied directly to the eye with contact lens wear and the spray is sprayed on to the closed eyelid margins with contact lens wear. To monitor adherence a patient check list will be provided for the participants. The washout period between each treatment is a minimum 48 hours.
Sponsors
Brien Holden Vision Institute
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Habitual contact lens wear
Exclusion criteria
No history of contact lens wear
Outcome results
None listed