None listed
Conditions
Brief summary
The aim of the work is compare artificial endometrial preparation by oestrogen and progesterone versus pretreatment with Gonadotrophin-releasing hormone agonist (GnRha), oestrogen and progesterone for cryo embryo transfer according to clinical pregnancy rate.
Interventions
Group B (intervention group):
Patient will be treated with the GnRh-analouge, triptorelin 0.1mg/day subcutaneously beginning in the mid luteal phase of the previous menstrual cycle and continuing till the date of embryo transfer. Full pituitary desensitization will be ensured by measuring serum estradiol on the first day of the menstrual cycle and should be less than 50 picogram /dl
Endometrial preparation will begin from third day of menstruation by oral Estradiol valerate 8mg/day till en
Group B (intervention group): Patient will be treated with the GnRh-analouge, triptorelin 0.1mg/day subcutaneously beginning in the mid luteal phase of the previous menstrual cycle and continuing till the date of embryo transfer. Full pituitary desensitization will be ensured by measuring serum estradiol on the first day of the menstrual cycle and should be less than 50 picogram /dl Endometrial preparation will begin from third day of menstruation by oral Estradiol valerate 8mg/day till endomtrium exceeding 8.5mm, then progesterone administration rectal suppository 400mg Am and intramuscular 100mg Pm.
Sponsors
Elshatby University Maternity Hospital Department of Obstetrics and Gynecology
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator)
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 35 years old or less. 2. Infertility: primary or secondary 3. Embryos: were frozen on day five. 4. Cryopreservation: closed method vitrification 5. Laser assisted hatching prior to embryo transfer.
Exclusion criteria
1. Age above 35 years old. 2. Abnormal uterine factor diagnosed by Vaginal sonography, Hysteroscopy or Hysterosalpingography
Outcome results
None listed