Outcomes of single dose peri-procedural antibiotic prophylaxis for endoscopic ultrasound guided fine needle aspiration of pancreatic cystic lesions.

Rates of infection in patients with pancreatic cyst endoscopic ultrasound fine needle aspiration given antibiotic prophylaxis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12613001305718

Enrollment

100

Registered

2013-11-22

Start date

2011-02-04

Completion date

2016-01-10

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Endoscopic ultrasound can obtain fluid using a technique known as fine needle aspiration (FNA). This involves a needle entering a pancreatic cyst and sucking fluid out. However, this test risks introducing gut bacteria into a normally sterile space. As such antibiotics may be effective to prevent infections. We aim to test whether Tazocin or Ciprofloxacin if penicillin allergy is present, prevents infections or is associated with increased harm.

Interventions

Patients having endoscopic ultrasound fine needle aspiration are at risk of iatrogenic infections due to the procedure. Currently there are no firm guidelines as to whether antibiotics are required or if they are, what antibiotics should be used. There have been no studies focusing on Tazocin (tazobactam, piperacillin) at the time of endoscopic ultrasound fine needle aspiration (EUS FNA). We will include all cases of EUS FNA requiring antibiotic prophylaxis and follow up patients following discharge home to determine whether they develop acute or chronic infections. Observational study will be conducted determining the rates of sepsis following EUS FNA (single periprocedural dose IV tazocin or ciprofloxacin) on telephone follow up 1 year post-procedure

Eligibility

Sex/Gender

All

Age

16 Years to 90 Years

Healthy volunteers

Inclusion criteria

Age 16 - 90 Pancreatic cyst requiring fine needle aspiration Consenting to procedure

Exclusion criteria

Coagulopathy Not possible to safely perform EUS FNA eg cyst not well-positioned

Outcome results